Digoxin and Nicardipine Interaction
Drug interaction information between Digoxin and Nicardipine.
Digoxin and Nicardipine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Digoxin and Nicardipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Nicardipine may cause digoxin to build up in your bloodstream by changing how your body handles the drug.
FDA Label Information
Digoxin Some calcium blockers may increase the concentration of digitalis preparations in the blood. Nicardipine hydrochloride capsules usually do not alter the plasma levels of digoxin; however, serum digoxin levels should be evaluated after concomitant therapy with nicardipine hydrochloride capsules are initiated.
Digoxin Also Interacts With
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
- Dopamine moderate
Nicardipine Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Tacrolimus Topical moderate
- Furosemide minor
- Propranolol minor
- Naproxen minor
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Nicardipine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Nicardipine's 14. In the major band specifically: Digoxin has 2 (also Posaconazole); Nicardipine has 1.
What mechanism field is on file for Digoxin and Nicardipine?
Nicardipine may cause digoxin to build up in your bloodstream by changing how your body handles the drug.
Digoxin carries more major-labeled pairs than Nicardipine
SPL source-record counts only. This page's band is major · classes on file: Digoxin (Cardiac Glycoside); Nicardipine (Calcium Channel Blocker).
Digoxin has 2 major-labeled pairs vs Nicardipine's 1.
1 major · 2 moderate · 11 minor · 14 total
Nicardipine has no other major-band peer in this dataset besides Digoxin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.