Trandolapril and Lithium Interaction
Drug interaction information between Trandolapril and Lithium.
Trandolapril and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Trandolapril and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Trandolapril can make it harder for your body to clear lithium, which may cause the lithium to build up to toxic levels.
FDA Label Information
Lithium Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.
Trandolapril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Amiloride moderate
- Furosemide minor
- Warfarin minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Trandolapril's 8. In the moderate band specifically: Trandolapril has 3 (also Spironolactone, Amiloride); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Trandolapril and Lithium?
Trandolapril can make it harder for your body to clear lithium, which may cause the lithium to build up to toxic levels.
Lithium carries more major-labeled pairs than Trandolapril
SPL source-record counts only. This page's band is moderate · classes on file: Trandolapril (ACE Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Trandolapril's 1. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 4 minor · 8 total
- Other moderate peers for Trandolapril
- Spironolactone
- Amiloride
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.