Trandolapril and Amiloride Interaction
Drug interaction information between Trandolapril and Amiloride.
Trandolapril and Amiloride have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Trandolapril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both prevent the body from removing potassium, which can cause potassium levels in your blood to become too high.
FDA Label Information
Use of potassium-sparing diuretics (spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes concomitantly with ACE inhibitors can increase the risk of hyperkalemia.
Trandolapril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Furosemide minor
- Warfarin minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Amiloride?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Trandolapril's 8. In the moderate band specifically: Trandolapril has 3 (also Spironolactone, Lithium); Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Benazepril).
What mechanism field is on file for Trandolapril and Amiloride?
These drugs both prevent the body from removing potassium, which can cause potassium levels in your blood to become too high.
Amiloride's labeled portfolio outnumbers Trandolapril
SPL source-record counts only. This page's band is moderate · classes on file: Trandolapril (ACE Inhibitor); Amiloride (Potassium-Sparing Diuretic).
1 major · 3 moderate · 4 minor · 8 total
- Other moderate peers for Trandolapril
- Spironolactone
- Lithium
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.