What the FDA labels say about taking them together
Digoxin and ivabradine
Digoxin's FDA label of December 5, 2024 names ivabradine in its drug interactions section, and ivabradine's label names digoxin too. The digoxin label: “Ivabradine Can increase the risk of bradycardia.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ivabradine FDA label on DailyMed (effective November 10, 2025).
What does the digoxin label say about ivabradine?
Digoxin label, drug interactionsHyperpolarization-activated cyclic nucleotide-gated channel blocker; Ivabradine; Can increase the risk of bradycardia
Lanoxin label (Covis Pharma US, Inc, October 17, 2025), drug interactionsIvabradine Can increase the risk of bradycardia.
Source: FDA drug label (Lanoxin, NDA009330), Covis Pharma US, Inc, effective October 17, 2025 (SPL set 9ec84cac-6ecc-43dc-8006-6ccc029e2707), via openFDA
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the ivabradine label say about digoxin?
Ivabradine label, drug interactionsThe risk of bradycardia increases with concomitant administration of drugs that slow heart rate (e.g., digoxin, amiodarone, beta-blockers).
Ivabradine label, warnings and precautionsRisk factors for bradycardia include sinus node dysfunction, conduction defects (e.g., 1 st or 2 nd degree atrioventricular block, bundle branch block), ventricular dyssynchrony, and use of other negative chronotropes (e.g., digoxin, diltiazem, verapamil, amiodarone).
Source: FDA drug label (Corlanor), Amgen Inc, effective November 10, 2025 (SPL set 92018a65-38f6-45f7-91d4-a34921b81d0d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Ivabradine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Heart failure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.761 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once