Digoxin and Ivabradine Interaction
Drug interaction information between Digoxin and Ivabradine.
Digoxin and Ivabradine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Digoxin and Ivabradine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications work to slow down the heart. When taken together, they can cause the heart rate to drop to a level that is too slow.
FDA Label Information
Hyperpolarization-activated cyclic nucleotide-gated channel blocker Ivabradine Can increase the risk of bradycardia.
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Dopamine moderate
Ivabradine Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem moderate
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Ivabradine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Ivabradine's 10. In the moderate band specifically: Digoxin has 13 (also Sotalol, Dofetilide, Dopamine, Epinephrine); Ivabradine has 2 (also Diltiazem).
What mechanism field is on file for Digoxin and Ivabradine?
Both of these medications work to slow down the heart. When taken together, they can cause the heart rate to drop to a level that is too slow.
Ivabradine carries more major-labeled pairs than Digoxin
SPL source-record counts only. This page's band is moderate · classes on file: Digoxin (Cardiac Glycoside); Ivabradine (HCN Channel Blocker).
Ivabradine has 4 major-labeled pairs vs Digoxin's 2. This page itself is in the moderate band, not the major band.
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Dopamine
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.