Trandolapril and Warfarin Interaction
Drug interaction information between Trandolapril and Warfarin.
Trandolapril and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trandolapril and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Trandolapril does not change how well warfarin works to thin your blood. The two drugs do not have a meaningful interaction.
FDA Label Information
The anticoagulant effect of warfarin was not significantly changed by trandolapril.
Trandolapril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Furosemide minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Trandolapril's 8. In the minor band specifically: Trandolapril has 4 (also Furosemide, Digoxin, Cimetidine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Trandolapril and Warfarin?
Trandolapril does not change how well warfarin works to thin your blood. The two drugs do not have a meaningful interaction.
Warfarin carries more major-labeled pairs than Trandolapril
SPL source-record counts only. This page's band is minor · classes on file: Trandolapril (ACE Inhibitor); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Trandolapril's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 4 minor · 8 total
- Other minor peers for Trandolapril
- Furosemide
- Digoxin
- Cimetidine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.