Trandolapril and Aliskiren Interaction
Drug interaction information between Trandolapril and Aliskiren.
Trandolapril and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Trandolapril and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs target the same system for controlling blood pressure, which can overwork the kidneys. This increases the risk of very low blood pressure and high potassium levels.
FDA Label Information
Drug Interactions Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with trandolapril in patients with diabetes. Avoid use of aliskiren with trandolapril in patients with renal impairment (GFR <60 mL/min).
Trandolapril Also Interacts With
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Furosemide minor
- Warfarin minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Trandolapril's 8. In the major band specifically: Trandolapril has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Trandolapril and Aliskiren?
Both drugs target the same system for controlling blood pressure, which can overwork the kidneys. This increases the risk of very low blood pressure and high potassium levels.
Aliskiren carries more major-labeled pairs than Trandolapril
SPL source-record counts only. This page's band is major · classes on file: Trandolapril (ACE Inhibitor); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Trandolapril's 1.
1 major · 3 moderate · 4 minor · 8 total
Trandolapril has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.