Digoxin and Dofetilide Interaction
Drug interaction information between Digoxin and Dofetilide.
Digoxin and Dofetilide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Digoxin and Dofetilide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Both drugs change how electricity moves through the heart.
What To Do
Your doctor will need to monitor your heart's electrical activity very closely. Seek medical help if you feel faint or have chest palpitations.
FDA Label Information
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Ivabradine moderate
- Dopamine moderate
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
Frequently Asked Questions
Can I take Digoxin and Dofetilide together?
This is a moderate interaction. Your doctor will need to monitor your heart's electrical activity very closely. Seek medical help if you feel faint or have chest palpitations.
How serious is the interaction between Digoxin and Dofetilide?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Digoxin and Dofetilide interact?
Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Both drugs change how electricity moves through the heart.
Understanding the Digoxin and Dofetilide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Digoxin belongs to the Cardiac Glycoside class and Dofetilide belongs to the Class III Antiarrhythmic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Digoxin has 120 total documented interactions on file in this dataset, and Dofetilide has 8. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor will need to monitor your heart's electrical activity very closely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Digoxin or Dofetilide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.