Trandolapril and Cimetidine Interaction
Drug interaction information between Trandolapril and Cimetidine.
Trandolapril and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trandolapril and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no known significant interaction between these two drugs in how the body processes them.
FDA Label Information
Other No clinically significant pharmacokinetic interaction has been found between trandolaprilat and food, cimetidine, digoxin, or furosemide.
Trandolapril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amiloride moderate
- Furosemide minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Trandolapril + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Trandolapril's 8. In the minor band specifically: Trandolapril has 4 (also Furosemide, Warfarin, Digoxin); Cimetidine has 63 (also Albendazole, Alogliptin, Alosetron, Alprazolam).
What mechanism field is on file for Trandolapril and Cimetidine?
There is no known significant interaction between these two drugs in how the body processes them.
Cimetidine carries more major-labeled pairs than Trandolapril
SPL source-record counts only. This page's band is minor · classes on file: Trandolapril (ACE Inhibitor); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Trandolapril's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 4 minor · 8 total
- Other minor peers for Trandolapril
- Furosemide
- Warfarin
- Digoxin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alogliptin
- Alosetron
- Alprazolam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.