Prescription medication · ACE Inhibitor
trandolapril
Also sold as Mavik. Trandolapril is used to treat high blood pressure.
Data updated 2026-05-15
- 1,978
- FDA reportsRarely reported
- 8
- InteractionsFew interactions
- $0.17
- Generic price (NADAC)
What the data shows
trandolapril (Mavik) is a prescription ACE Inhibitor, among the least-reported drugs the FDA tracks (1,978 FDA reports), with 8 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
trandolapril (Mavik) is a prescription ACE Inhibitor. Trandolapril is used to treat high blood pressure.
Trandolapril (Mavik) is a medicine that lowers blood pressure. It can also help people who have had a heart attack and have a weak heart.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Generic Price
$0.17/unit
Generic Available
Yes (4 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Trandolapril is used to treat high blood pressure.
Common side effects
Cough, Dizziness
Key warnings
If you become pregnant, stop taking trandolapril right away.
The sections below are summarized in plain English from trandolapril's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Trandolapril belongs to a class of drugs called ACE inhibitors. It works by blocking a substance in your body that tightens blood vessels. This helps your blood vessels relax and lowers your blood pressure.
Side Effects (from patient reports)
Based on 1,978 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for trandolapril, by number of reports
- Dyspnoea
Dyspnoea
137 reports
- Fatigue
Fatigue
119 reports
- Dizziness
Dizziness
108 reports
- Diarrhoea
Diarrhoea
99 reports
- Cough
Cough
97 reports
- Asthenia
Asthenia
90 reports
- Nausea
Nausea
85 reports
- Drug Interaction
Drug Interaction
82 reports
- Toxicity To Various Agents
Toxicity To Various Agents
78 reports
- Hypertension
Hypertension
75 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for trandolapril each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where trandolapril sits
trandolapril has more FDA adverse-event reports than 12% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is trandolapril; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,978 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2004–2025.
Total Reports
1,978
Reports Mentioning Death
192
9.7% of reports — not proof of cause
Hospitalization Reports
987
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DYSPNOEA | 137 |
| 2 | FATIGUE | 119 |
| 4 | DIZZINESS | 108 |
| 5 | DIARRHOEA | 99 |
| 6 | COUGH | 97 |
| 7 | ASTHENIA | 90 |
| 8 | NAUSEA | 85 |
| 9 | DRUG INTERACTION | 82 |
| 11 | TOXICITY TO VARIOUS AGENTS | 78 |
| 12 | HYPERTENSION | 75 |
| 13 | HYPOTENSION | 74 |
| 14 | ARTHRALGIA | 68 |
| 15 | PYREXIA | 66 |
| 16 | HEADACHE | 65 |
| 17 | LACTIC ACIDOSIS | 63 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
If you become pregnant, stop taking trandolapril right away. This medicine can harm or cause death to your unborn baby.
Known Drug Interactions
Drug Interactions Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with trandolapril in patients with diabetes. Avoid use of aliskiren with trandolapril in patients with renal impairment (GFR <60 mL/min).
Mechanism: Both drugs target the same system for controlling blood pressure, which can overwork the kidneys. This increases the risk of very low blood pressure and high potassium levels.
Use of potassium-sparing diuretics (spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes concomitantly with ACE inhibitors can increase the risk of hyperkalemia.
Mechanism: Both of these medicines cause the body to keep potassium instead of getting rid of it, which can lead to dangerously high levels in the blood.
Lithium Increased serum lithium levels and symptoms of lithium toxicity have been reported in patients receiving concomitant lithium and ACE inhibitor therapy. These drugs should be coadministered with caution, and frequent monitoring of serum lithium levels is recommended. If a diuretic is also used, the risk of lithium toxicity may be increased.
Mechanism: Trandolapril can make it harder for your body to clear lithium, which may cause the lithium to build up to toxic levels.
Use of potassium-sparing diuretics (spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes concomitantly with ACE inhibitors can increase the risk of hyperkalemia.
Mechanism: These drugs both prevent the body from removing potassium, which can cause potassium levels in your blood to become too high.
Other No clinically significant pharmacokinetic interaction has been found between trandolaprilat and food, cimetidine, digoxin, or furosemide.
Mechanism: Studies show that these two medications do not interfere with each other in the body. They can be processed by the body at the same time without issues.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
Can I take trandolapril with other blood pressure medicines?
What should I do if I feel dizzy after taking trandolapril?
Can I drink alcohol while taking trandolapril?
Does trandolapril interact with any other medications?
Can I take potassium supplements while taking trandolapril?
How long does it take for trandolapril to start working?
What if my blood pressure is still high after taking trandolapril for a while?
Can trandolapril cause kidney problems?
Is it safe to drive while taking trandolapril?
Can I stop taking trandolapril if my blood pressure is normal?
What are the common side effects of trandolapril?
Does trandolapril interact with other medications?
What drug class is trandolapril?
What pregnancy or breastfeeding source fields are listed for trandolapril?
Related Medications in ACE Inhibitor
Other drugs grouped near trandolapril - same-class peers and common alternatives.
acebutolol
Sectral
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats.
Compare with trandolapril →
aliskiren
Tekturna
Tekturna is a medicine used to treat high blood pressure.
Compare with trandolapril →
amiloride
Midamor
Amiloride is a water pill that helps your body hold onto potassium.
Compare with trandolapril →
amlodipine
Norvasc
Amlodipine (Norvasc) is a drug that lowers blood pressure and treats chest pain.
Compare with trandolapril →
amlodipine/benazepril
Lotrel
Lotrel is a combination medicine that contains amlodipine and benazepril.
Compare with trandolapril →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for trandolapril: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 1,978.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 9.71%.
- azithromycin Δ 0.00 pts · 37,361 reports · Macrolide Antibiotic 9.71%death share
- promethazine Δ 0.05 pts · 17,969 reports · Phenothiazine Antiemetic / Antihistamine 9.76%death share
- nebivolol Δ 0.06 pts · 14,997 reports · Beta-1 Selective Blocker 9.76%death share
- doxycycline Δ 0.06 pts · 64,488 reports · Tetracycline Antibiotic 9.76%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for trandolapril
The FDA label for trandolapril (sold under brand names such as Mavik) classifies it as a prescription-only medication in the ACE Inhibitor class. Trandolapril is used to treat high blood pressure. Official labeling lists 2 commonly reported side effects, including Cough, Dizziness.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,978 voluntary reports. The database also lists 8 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $0.17.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: April 18, 2024
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages