digoxin vs trandolapril
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of digoxin and trandolapril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Other No clinically significant pharmacokinetic interaction has been found between trandolaprilat and food, cimetidine, digoxin, or furosemide.
Lanoxin
Mavik
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Trandolapril (Mavik) is a medicine that lowers blood pressure. It can also help people who have had a heart attack and have a weak heart.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Trandolapril is used to treat high blood pressure. It can be used alone or with other blood pressure medicines. It is also used in people who have had a heart attack and have a weak heart (left ventricular dysfunction) or heart failure.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Trandolapril belongs to a class of drugs called ACE inhibitors. It works by blocking a substance in your body that tightens blood vessels. This helps your blood vessels relax and lowers your blood pressure.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Cough
- • Dizziness
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Dyspnoea 137
- Fatigue 119
- Dizziness 108
- Diarrhoea 99
- Cough 97
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
If you become pregnant, stop taking trandolapril right away. This medicine can harm or cause death to your unborn baby.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Do not take trandolapril if you are pregnant. It can cause serious harm to your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
Also Compare, Nearby Drugs
Compare trandolapril with
How to Read This digoxin vs trandolapril Comparison
digoxin is classified in the Cardiac Glycoside drug class, while trandolapril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while trandolapril has 560. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs do not affect how the body absorbs or gets rid of each other. there is no known significant interaction between them.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or trandolapril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.