Digoxin and Sotalol Interaction
Drug interaction information between Digoxin and Sotalol.
Digoxin and Sotalol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Digoxin and Sotalol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together can increase the chance of developing dangerous, irregular heartbeats. This may be due to the drugs themselves or the heart condition being treated.
FDA Label Information
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Dofetilide moderate
- Ivabradine moderate
- Dopamine moderate
Sotalol Also Interacts With
- Clonidine moderate
- Amiodarone moderate
- Clarithromycin moderate
- Albuterol minor
- Diltiazem minor
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Sotalol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Sotalol's 13. In the moderate band specifically: Digoxin has 13 (also Dofetilide, Ivabradine, Dopamine, Epinephrine); Sotalol has 4 (also Clonidine, Amiodarone, Clarithromycin).
What mechanism field is on file for Digoxin and Sotalol?
Using these two drugs together can increase the chance of developing dangerous, irregular heartbeats. This may be due to the drugs themselves or the heart condition being treated.
Digoxin carries more major-labeled pairs than Sotalol
SPL source-record counts only. This page's band is moderate · classes on file: Digoxin (Cardiac Glycoside); Sotalol (Class III Antiarrhythmic / Beta-Blocker).
Digoxin has 2 major-labeled pairs vs Sotalol's 0. This page itself is in the moderate band, not the major band.
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Dofetilide
- Ivabradine
- Dopamine
- Epinephrine
0 major · 4 moderate · 9 minor · 13 total
- Other moderate peers for Sotalol
- Clonidine
- Amiodarone
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.