Digoxin and Posaconazole Interaction
Drug interaction information between Digoxin and Posaconazole.
Digoxin and Posaconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Digoxin and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Posaconazole can cause the amount of digoxin in your blood to rise to higher levels. This increases the risk of digoxin toxicity, which can affect your heart rhythm.
FDA Label Information
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets. 7.12 Digoxin Increased plasma concentrations of...
Digoxin Also Interacts With
- Nicardipine major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
- Dopamine moderate
Posaconazole Also Interacts With
- Esomeprazole major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
- Efavirenz/Emtricitabine/Tenofovir moderate
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Posaconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Posaconazole's 27. In the major band specifically: Digoxin has 2 (also Nicardipine); Posaconazole has 5 (also Esomeprazole, Cimetidine, Metoclopramide, Phenytoin).
What mechanism field is on file for Digoxin and Posaconazole?
Posaconazole can cause the amount of digoxin in your blood to rise to higher levels. This increases the risk of digoxin toxicity, which can affect your heart rhythm.
Posaconazole carries more major-labeled pairs than Digoxin
SPL source-record counts only. This page's band is major · classes on file: Digoxin (Cardiac Glycoside); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Digoxin's 2.
5 major · 5 moderate · 17 minor · 27 total
- Other major peers for Posaconazole
- Esomeprazole
- Cimetidine
- Metoclopramide
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.