Digoxin and Metformin Interaction
Drug interaction information between Digoxin and Metformin.
Digoxin and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Digoxin and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking metformin can cause the amount of digoxin in your blood to rise. It is not yet known exactly how much the levels will increase.
FDA Label Information
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Metformin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Metformin's 27. In the minor band specifically: Digoxin has 105 (also Omeprazole, Ibuprofen, Diclofenac, Ketoconazole); Metformin has 17 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine).
What mechanism field is on file for Digoxin and Metformin?
Taking metformin can cause the amount of digoxin in your blood to rise. It is not yet known exactly how much the levels will increase.
Digoxin carries more major-labeled pairs than Metformin
SPL source-record counts only. This page's band is minor · classes on file: Digoxin (Cardiac Glycoside); Metformin (Biguanide).
Digoxin has 2 major-labeled pairs vs Metformin's 0. This page itself is in the minor band, not the major band.
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Omeprazole
- Ibuprofen
- Diclofenac
- Ketoconazole
0 major · 10 moderate · 17 minor · 27 total
- Other minor peers for Metformin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.