Sulfasalazine and Methylprednisolone Interaction
Drug interaction information between Sulfasalazine and Methylprednisolone.
Sulfasalazine and Methylprednisolone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sulfasalazine and Methylprednisolone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sulfasalazine is linked to a condition called methemoglobinemia, which reduces the amount of oxygen your blood can carry to your tissues. Combining it with other drugs may increase this risk.
FDA Label Information
Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine...
Sulfasalazine Also Interacts With
- Lidocaine Topical moderate
- Sofosbuvir/Velpatasvir moderate
- Digoxin minor
- Drospirenone/Ethinyl Estradiol minor
- Etanercept minor
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Methylprednisolone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylprednisolone has 29 labeled pairs on file vs Sulfasalazine's 7. In the minor band specifically: Sulfasalazine has 5 (also Digoxin, Drospirenone, Etanercept, Prenatal Multivitamin); Methylprednisolone has 22 (also Acetaminophen, Warfarin, Nitrofurantoin, Valproate).
What mechanism field is on file for Sulfasalazine and Methylprednisolone?
Sulfasalazine is linked to a condition called methemoglobinemia, which reduces the amount of oxygen your blood can carry to your tissues. Combining it with other drugs may increase this risk.
Methylprednisolone carries more major-labeled pairs than Sulfasalazine
SPL source-record counts only. This page's band is minor · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Methylprednisolone (Corticosteroid).
Methylprednisolone has 1 major-labeled pair vs Sulfasalazine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Sulfasalazine
- Digoxin
- Drospirenone
- Etanercept
- Prenatal Multivitamin
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Warfarin
- Nitrofurantoin
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.