Methylprednisolone and Warfarin Interaction
Drug interaction information between Methylprednisolone and Warfarin.
Methylprednisolone and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylprednisolone and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can make the blood thinner less effective, though the effect can sometimes be unpredictable. This means your blood may not be as thin as it needs to be to prevent clots.
FDA Label Information
Anticoagulants , oral : Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Methylprednisolone's 29. In the minor band specifically: Methylprednisolone has 22 (also Acetaminophen, Nitrofurantoin, Valproate, Cyclosporine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Methylprednisolone and Warfarin?
Taking these drugs together can make the blood thinner less effective, though the effect can sometimes be unpredictable. This means your blood may not be as thin as it needs to be to prevent clots.
Warfarin carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is minor · classes on file: Methylprednisolone (Corticosteroid); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Nitrofurantoin
- Valproate
- Cyclosporine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.