Methylprednisolone and Valproate Interaction
Drug interaction information between Methylprednisolone and Valproate.
Methylprednisolone and Valproate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylprednisolone and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs at the same time may increase the chance of developing a blood problem that lowers the oxygen levels in your body. This happens because both drugs are associated with a condition called methemoglobinemia.
FDA Label Information
Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine...
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Valproate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Methylprednisolone's 29. In the minor band specifically: Methylprednisolone has 22 (also Acetaminophen, Warfarin, Nitrofurantoin, Cyclosporine); Valproate has 36 (also Aspirin, Clonazepam, Topiramate, Amitriptyline).
What mechanism field is on file for Methylprednisolone and Valproate?
Using these two drugs at the same time may increase the chance of developing a blood problem that lowers the oxygen levels in your body. This happens because both drugs are associated with a condition called methemoglobinemia.
Valproate carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is minor · classes on file: Methylprednisolone (Corticosteroid); Valproate (Anticonvulsant / Mood Stabilizer).
Valproate has 2 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Warfarin
- Nitrofurantoin
- Cyclosporine
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Aspirin
- Clonazepam
- Topiramate
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.