Methylprednisolone and Nitrofurantoin Interaction
Drug interaction information between Methylprednisolone and Nitrofurantoin.
Methylprednisolone and Nitrofurantoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylprednisolone and Nitrofurantoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can both contribute to a blood disorder that prevents oxygen from reaching your body's tissues properly. This is a rare but serious side effect mentioned in the drug safety information.
FDA Label Information
Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine...
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Nitrofurantoin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Probenecid minor
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Nitrofurantoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylprednisolone has 29 labeled pairs on file vs Nitrofurantoin's 4. In the minor band specifically: Methylprednisolone has 22 (also Acetaminophen, Warfarin, Valproate, Cyclosporine); Nitrofurantoin has 2 (also Probenecid).
What mechanism field is on file for Methylprednisolone and Nitrofurantoin?
These medications can both contribute to a blood disorder that prevents oxygen from reaching your body's tissues properly. This is a rare but serious side effect mentioned in the drug safety information.
Methylprednisolone carries more major-labeled pairs than Nitrofurantoin
SPL source-record counts only. This page's band is minor · classes on file: Methylprednisolone (Corticosteroid); Nitrofurantoin (Nitrofuran Antibiotic).
Methylprednisolone has 1 major-labeled pair vs Nitrofurantoin's 0. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Acetaminophen
- Warfarin
- Valproate
- Cyclosporine
0 major · 2 moderate · 2 minor · 4 total
- Other minor peers for Nitrofurantoin
- Probenecid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.