Methylprednisolone and Aprepitant Interaction
Drug interaction information between Methylprednisolone and Aprepitant.
Methylprednisolone and Aprepitant have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methylprednisolone and Aprepitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aprepitant prevents the body from breaking down methylprednisolone, which leads to higher levels of the steroid in your system.
FDA Label Information
Single 40 mg dose of aprepitant No dosage adjustment of oral dexamethasone needed Methylprednisolone Clinical Impact Increased methylprednisolone exposure [see Clinical Pharmacology ( 12.3 )]. Intervention 3-day aprepitant regimen Reduce the dose of intravenous methylprednisolone by approximately 25% Reduce the dose of oral methylprednisolone by approximately 50% Single 40 mg dose of aprepitant No dosage adjustment of methylprednisolone needed Chemotherapeutic agents that are metabolized by CYP3A4 Clinical Impact Increased exposure of the chemotherapeutic agent may increase the risk of...
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Clarithromycin moderate
- Darunavir moderate
Aprepitant Also Interacts With
- Pimozide major
- Alprazolam moderate
- Diltiazem moderate
- Ketoconazole moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Aprepitant?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylprednisolone has 29 labeled pairs on file vs Aprepitant's 22. In the moderate band specifically: Methylprednisolone has 6 (also Aspirin, Ketoconazole, Clarithromycin, Darunavir); Aprepitant has 9 (also Alprazolam, Diltiazem, Ketoconazole, Clarithromycin).
What mechanism field is on file for Methylprednisolone and Aprepitant?
Aprepitant prevents the body from breaking down methylprednisolone, which leads to higher levels of the steroid in your system.
Methylprednisolone's labeled portfolio outnumbers Aprepitant
SPL source-record counts only. This page's band is moderate · classes on file: Methylprednisolone (Corticosteroid); Aprepitant (NK1 Receptor Antagonist (Antiemetic)).
1 major · 6 moderate · 22 minor · 29 total
- Other moderate peers for Methylprednisolone
- Aspirin
- Ketoconazole
- Clarithromycin
- Darunavir
1 major · 9 moderate · 12 minor · 22 total
- Other moderate peers for Aprepitant
- Alprazolam
- Diltiazem
- Ketoconazole
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.