Sulfasalazine and Digoxin Interaction
Drug interaction information between Sulfasalazine and Digoxin.
Sulfasalazine and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sulfasalazine and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sulfasalazine can decrease the amount of digoxin in your blood, making the heart medicine less effective.
FDA Label Information
John's Wort, sucralfate, sulfasalazine Measure serum digoxin concentrations before initiating concomitant drugs.
Sulfasalazine Also Interacts With
- Lidocaine Topical moderate
- Sofosbuvir/Velpatasvir moderate
- Drospirenone/Ethinyl Estradiol minor
- Etanercept minor
- Methylprednisolone minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Sulfasalazine's 7. In the minor band specifically: Sulfasalazine has 5 (also Drospirenone, Etanercept, Methylprednisolone, Prenatal Multivitamin); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Sulfasalazine and Digoxin?
Sulfasalazine can decrease the amount of digoxin in your blood, making the heart medicine less effective.
Digoxin carries more major-labeled pairs than Sulfasalazine
SPL source-record counts only. This page's band is minor · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Sulfasalazine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Sulfasalazine
- Drospirenone
- Etanercept
- Methylprednisolone
- Prenatal Multivitamin
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.