Sulfasalazine and Etanercept Interaction
Drug interaction information between Sulfasalazine and Etanercept.
Sulfasalazine and Etanercept have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sulfasalazine and Etanercept. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two medicines together can lower the number of white blood cells that help your body fight infections.
FDA Label Information
7.4 Sulfasalazine Patients in a clinical study who were on established therapy with sulfasalazine, to which Enbrel was added, were noted to develop a mild decrease in mean neutrophil counts in comparison to groups treated with either Enbrel or sulfasalazine alone.
Sulfasalazine Also Interacts With
- Lidocaine Topical moderate
- Sofosbuvir/Velpatasvir moderate
- Digoxin minor
- Drospirenone/Ethinyl Estradiol minor
- Methylprednisolone minor
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Etanercept?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sulfasalazine has 7 labeled pairs on file vs Etanercept's 2. In the minor band specifically: Sulfasalazine has 5 (also Digoxin, Drospirenone, Methylprednisolone, Prenatal Multivitamin); Etanercept has 1.
What mechanism field is on file for Sulfasalazine and Etanercept?
Taking these two medicines together can lower the number of white blood cells that help your body fight infections.
Sulfasalazine's labeled portfolio outnumbers Etanercept
SPL source-record counts only. This page's band is minor · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Etanercept (TNF-Alpha Inhibitor (Biologic)).
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Sulfasalazine
- Digoxin
- Drospirenone
- Methylprednisolone
- Prenatal Multivitamin
0 major · 1 moderate · 1 minor · 2 total
Etanercept has no other minor-band peer in this dataset besides Sulfasalazine.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.