Sulfasalazine and Drospirenone Interaction
Drug interaction information between Sulfasalazine and Drospirenone.
Sulfasalazine and Drospirenone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sulfasalazine and Drospirenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sulfasalazine can lower the levels of folate in your body by blocking a specific enzyme that helps process it.
FDA Label Information
7.5 Effects of Other Drugs on Folates Several drugs have been reported to reduce folate concentrations by inhibition of the dihydrofolate reductase enzyme (e.g., methotrexate and sulfasalazine) or by reducing folate absorption (e.g., cholestyramine), or via unknown mechanisms (e.g., antiepileptics such as carbamazepine, phenytoin, phenobarbital, primidone and valproic acid).
Sulfasalazine Also Interacts With
- Lidocaine Topical moderate
- Sofosbuvir/Velpatasvir moderate
- Digoxin minor
- Etanercept minor
- Methylprednisolone minor
Drospirenone Also Interacts With
- Estradiol major
- Atorvastatin minor
- Omeprazole minor
- Lamotrigine minor
- Topiramate minor
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Drospirenone/Ethinyl Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Drospirenone has 30 labeled pairs on file vs Sulfasalazine's 7. In the minor band specifically: Sulfasalazine has 5 (also Digoxin, Etanercept, Methylprednisolone, Prenatal Multivitamin); Drospirenone has 29 (also Atorvastatin, Omeprazole, Lamotrigine, Topiramate).
What mechanism field is on file for Sulfasalazine and Drospirenone/Ethinyl Estradiol?
Sulfasalazine can lower the levels of folate in your body by blocking a specific enzyme that helps process it.
Drospirenone carries more major-labeled pairs than Sulfasalazine
SPL source-record counts only. This page's band is minor · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Drospirenone (Combined Oral Contraceptive).
Drospirenone has 1 major-labeled pair vs Sulfasalazine's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Sulfasalazine
- Digoxin
- Etanercept
- Methylprednisolone
- Prenatal Multivitamin
1 major · 0 moderate · 29 minor · 30 total
- Other minor peers for Drospirenone
- Atorvastatin
- Omeprazole
- Lamotrigine
- Topiramate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.