Methylprednisolone and Ketoconazole Interaction
Drug interaction information between Methylprednisolone and Ketoconazole.
Methylprednisolone and Ketoconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methylprednisolone and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzymes that normally break down the steroid in your body. This causes the steroid levels to rise, which increases the risk of side effects.
FDA Label Information
Hepatic Enzyme Inhibitors (e.g., ketoconazole, macrolide antibiotics such as erythromycin and troleandomycin): Drugs which inhibit cytochrome P450 3A4 have the potential to result in increased plasma concentrations of corticosteroids. Ketoconazole : Ketoconazole has been reported to significantly decrease the metabolism of certain corticosteroids by up to 60%, leading to an increased risk of corticosteroid side effects.
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Aprepitant moderate
- Clarithromycin moderate
- Darunavir moderate
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Ketoconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Methylprednisolone's 29. In the moderate band specifically: Methylprednisolone has 6 (also Aspirin, Aprepitant, Clarithromycin, Darunavir); Ketoconazole has 22 (also Alprazolam, Aprepitant, Budesonide/Formoterol, Dexamethasone).
What mechanism field is on file for Methylprednisolone and Ketoconazole?
Ketoconazole blocks the enzymes that normally break down the steroid in your body. This causes the steroid levels to rise, which increases the risk of side effects.
Ketoconazole carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is moderate · classes on file: Methylprednisolone (Corticosteroid); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other moderate peers for Methylprednisolone
- Aspirin
- Aprepitant
- Clarithromycin
- Darunavir
6 major · 22 moderate · 85 minor · 113 total
- Other moderate peers for Ketoconazole
- Alprazolam
- Aprepitant
- Budesonide/Formoterol
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.