What the FDA labels say about taking them together
Aspirin and methylprednisolone
Methylprednisolone's FDA label of June 22, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name methylprednisolone. The methylprednisolone label: “Methylprednisolone may increase the clearance of chronic high-dose aspirin.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.).
What does the aspirin label say about methylprednisolone?
Aspirin's label (effective September 9, 2025) does not name methylprednisolone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the methylprednisolone label say about aspirin?
Methylprednisolone label, drug interactionsMethylprednisolone may increase the clearance of chronic high-dose aspirin.
Solu-Medrol label (Pharmacia & Upjohn Company LLC, December 2, 2025), drug interactionsNonsteroidal anti-inflammatory agents (NSAIDs): Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects.
Source: FDA drug label (Solu-Medrol, NDA011856), Pharmacia & Upjohn Company LLC, effective December 2, 2025 (SPL set cd99be87-c8d9-48d6-a8e5-e081052e3f19), via openFDA
Source: FDA drug label (Depo-Medrol, NDA011757), Pharmacia & Upjohn Company LLC, effective January 21, 2026 (SPL set 823b0010-2b57-4e76-b5ac-4a8c2963438f), via openFDA
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Methylprednisolone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.121 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once