Methylprednisolone and Aspirin Interaction
Drug interaction information between Methylprednisolone and Aspirin.
Methylprednisolone and Aspirin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Methylprednisolone and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can irritate the lining of the stomach and digestive tract. Taking them at the same time increases your risk of developing stomach pain or internal bleeding.
FDA Label Information
Nonsteroidal anti-inflammatory drugs (NSAIDs) : Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.
Methylprednisolone Also Interacts With
- Theophylline major
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
- Darunavir moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Aspirin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Methylprednisolone's 29. In the moderate band specifically: Methylprednisolone has 6 (also Ketoconazole, Aprepitant, Clarithromycin, Darunavir); Aspirin has 12 (also Alendronate, Apixaban, Desvenlafaxine, Dexamethasone).
What mechanism field is on file for Methylprednisolone and Aspirin?
Both of these medications can irritate the lining of the stomach and digestive tract. Taking them at the same time increases your risk of developing stomach pain or internal bleeding.
Aspirin carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is moderate · classes on file: Methylprednisolone (Corticosteroid); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the moderate band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other moderate peers for Methylprednisolone
- Ketoconazole
- Aprepitant
- Clarithromycin
- Darunavir
3 major · 12 moderate · 32 minor · 47 total
- Other moderate peers for Aspirin
- Alendronate
- Apixaban
- Desvenlafaxine
- Dexamethasone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.