Methylprednisolone and Acetaminophen Interaction
Drug interaction information between Methylprednisolone and Acetaminophen.
Methylprednisolone and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Methylprednisolone and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications are linked to a rare blood condition called methemoglobinemia, which reduces the blood's ability to carry oxygen. Taking them together may increase the risk of this condition occurring.
FDA Label Information
Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, isofamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine...
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methylprednisolone has 29 labeled pairs on file vs Acetaminophen's 23. In the minor band specifically: Methylprednisolone has 22 (also Warfarin, Nitrofurantoin, Valproate, Cyclosporine); Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine).
What mechanism field is on file for Methylprednisolone and Acetaminophen?
Both of these medications are linked to a rare blood condition called methemoglobinemia, which reduces the blood's ability to carry oxygen. Taking them together may increase the risk of this condition occurring.
Methylprednisolone carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Methylprednisolone (Corticosteroid); Acetaminophen (Analgesic / Antipyretic).
Methylprednisolone has 1 major-labeled pair vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
1 major · 6 moderate · 22 minor · 29 total
- Other minor peers for Methylprednisolone
- Warfarin
- Nitrofurantoin
- Valproate
- Cyclosporine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.