Sulfasalazine and Lidocaine Topical Interaction
Drug interaction information between Sulfasalazine and Lidocaine Topical.
Sulfasalazine and Lidocaine Topical have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sulfasalazine and Lidocaine Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a rare blood problem that prevents oxygen from reaching your body's tissues. Using them together makes this dangerous side effect more likely to happen.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Sulfasalazine Also Interacts With
- Sofosbuvir/Velpatasvir moderate
- Digoxin minor
- Drospirenone/Ethinyl Estradiol minor
- Etanercept minor
- Methylprednisolone minor
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Lidocaine Topical?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lidocaine Topical has 10 labeled pairs on file vs Sulfasalazine's 7. In the moderate band specifically: Sulfasalazine has 2 (also Sofosbuvir/Velpatasvir); Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Valproate, Chloroquine).
What mechanism field is on file for Sulfasalazine and Lidocaine Topical?
Both drugs can cause a rare blood problem that prevents oxygen from reaching your body's tissues. Using them together makes this dangerous side effect more likely to happen.
Lidocaine Topical's labeled portfolio outnumbers Sulfasalazine
SPL source-record counts only. This page's band is moderate · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Lidocaine Topical (Topical Anesthetic).
0 major · 2 moderate · 5 minor · 7 total
- Other moderate peers for Sulfasalazine
- Sofosbuvir/Velpatasvir
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Valproate
- Chloroquine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.