Methylprednisolone and Theophylline Interaction
Drug interaction information between Methylprednisolone and Theophylline.
Methylprednisolone and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Methylprednisolone and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Methylprednisolone can change the speed at which your body gets rid of theophylline. This can make the theophylline level in your blood unpredictable.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Methylprednisolone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
- Darunavir moderate
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Methylprednisolone + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Methylprednisolone's 29. In the major band specifically: Methylprednisolone has 1; Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Methylprednisolone and Theophylline?
Methylprednisolone can change the speed at which your body gets rid of theophylline. This can make the theophylline level in your blood unpredictable.
Theophylline carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is major · classes on file: Methylprednisolone (Corticosteroid); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Methylprednisolone's 1.
1 major · 6 moderate · 22 minor · 29 total
Methylprednisolone has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.