Sulfasalazine and Sofosbuvir/Velpatasvir Interaction
Drug interaction information between Sulfasalazine and Sofosbuvir/Velpatasvir.
Sulfasalazine and Sofosbuvir/Velpatasvir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Sulfasalazine and Sofosbuvir/Velpatasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medicine interferes with a protein that transports sulfasalazine, which could cause the levels of sulfasalazine in your body to rise.
FDA Label Information
Coadministration of VOSEVI with BCRP substrates (e.g., methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan) is not recommended [see Clinical Pharmacology (12.3) ].
Sulfasalazine Also Interacts With
- Lidocaine Topical moderate
- Digoxin minor
- Drospirenone/Ethinyl Estradiol minor
- Etanercept minor
- Methylprednisolone minor
Sofosbuvir/Velpatasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Pravastatin moderate
- Methotrexate moderate
Frequently Asked Questions
What SPL severity band is on file for Sulfasalazine + Sofosbuvir/Velpatasvir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sofosbuvir/Velpatasvir has 33 labeled pairs on file vs Sulfasalazine's 7. In the moderate band specifically: Sulfasalazine has 2 (also Lidocaine Topical); Sofosbuvir/Velpatasvir has 10 (also Pravastatin, Methotrexate, Cyclosporine, Carbamazepine).
What mechanism field is on file for Sulfasalazine and Sofosbuvir/Velpatasvir?
This medicine interferes with a protein that transports sulfasalazine, which could cause the levels of sulfasalazine in your body to rise.
Sofosbuvir/Velpatasvir carries more major-labeled pairs than Sulfasalazine
SPL source-record counts only. This page's band is moderate · classes on file: Sulfasalazine (Disease-Modifying Antirheumatic Drug (DMARD)); Sofosbuvir/Velpatasvir (NS5B/NS5A Inhibitor (HCV)).
Sofosbuvir/Velpatasvir has 3 major-labeled pairs vs Sulfasalazine's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other moderate peers for Sulfasalazine
- Lidocaine Topical
3 major · 10 moderate · 20 minor · 33 total
- Other moderate peers for Sofosbuvir/Velpatasvir
- Pravastatin
- Methotrexate
- Cyclosporine
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.