digoxin vs sulfasalazine
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of digoxin and sulfasalazine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
John's Wort, sucralfate, sulfasalazine Measure serum digoxin concentrations before initiating concomitant drugs.
Lanoxin
Azulfidine
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Sulfasalazine is a drug that reduces inflammation in the body. It is used to treat ulcerative colitis.
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
Sulfasalazine treats ulcerative colitis, a condition that causes inflammation and sores in the lining of the large intestine. It can help with mild to moderate ulcerative colitis. It can also be used with other treatments for severe ulcerative colitis. This medicine can also help keep ulcerative colitis from coming back.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Sulfasalazine is an anti-inflammatory drug. It works by reducing inflammation in the colon. The exact way it does this is not fully known.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Loss of appetite
- • Headache
- • Nausea
- • Vomiting
- • Stomach upset
- Dyspnoea 6,065
- Nausea 4,754
- Dizziness 4,439
- Fatigue 4,175
- Atrial Fibrillation 3,974
- Rheumatoid Arthritis 19,190
- Pain 15,658
- Arthralgia 13,161
- Fatigue 13,017
- Joint Swelling 12,481
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
You should not take this medicine if you have a blockage in your intestines or urinary tract. You should not take this medicine if you have porphyria, as it could cause an attack. You should not take this medicine if you are allergic to sulfasalazine, its ingredients, sulfonamides, or salicylates.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if Sulfasalazine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Also Compare, Nearby Drugs
Compare sulfasalazine with
How to Read This digoxin vs sulfasalazine Comparison
digoxin is classified in the Cardiac Glycoside drug class, while sulfasalazine sits within the Disease-Modifying Antirheumatic Drug (DMARD) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while sulfasalazine has 73,507. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to sulfasalazine can decrease the amount of digoxin in your blood, making the heart medicine less effective.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or sulfasalazine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.