Paroxetine and Clopidogrel Interaction
Drug interaction information between Paroxetine and Clopidogrel.
Paroxetine and Clopidogrel have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Paroxetine and Clopidogrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both try to attach to the same proteins in your blood. This can change the amount of active medicine in your body.
FDA Label Information
Examples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact Paroxetine is highly bound to plasma protein.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Clopidogrel Also Interacts With
- Omeprazole moderate
- Warfarin moderate
- Esomeprazole moderate
- Rifampin moderate
- Norepinephrine moderate
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Clopidogrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Clopidogrel's 19. In the minor band specifically: Paroxetine has 44 (also Buspirone, Aspirin, Venlafaxine, Warfarin); Clopidogrel has 10 (also Morphine, Repaglinide, Lansoprazole, Dexlansoprazole).
What mechanism field is on file for Paroxetine and Clopidogrel?
These drugs both try to attach to the same proteins in your blood. This can change the amount of active medicine in your body.
Paroxetine carries more major-labeled pairs than Clopidogrel
SPL source-record counts only. This page's band is minor · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Clopidogrel (Antiplatelet Agent).
Paroxetine has 3 major-labeled pairs vs Clopidogrel's 0. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Aspirin
- Venlafaxine
- Warfarin
0 major · 9 moderate · 10 minor · 19 total
- Other minor peers for Clopidogrel
- Morphine
- Repaglinide
- Lansoprazole
- Dexlansoprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.