Paroxetine and Pimozide Interaction
Drug interaction information between Paroxetine and Pimozide.
Paroxetine and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Paroxetine and Pimozide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine slows down how your body processes pimozide, causing the drug to build up to unsafe levels. High levels of pimozide can cause the heart to beat in a dangerous and irregular way.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Pimozide and Thioridazine Clinical Impact Increased plasma concentrations of pimozide and thioridazine, drugs with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias. Intervention Paroxetine is contraindicated in patients taking pimozide or thioridazine [see Contraindications ( 4 )] .
Paroxetine Also Interacts With
- Linezolid major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Pimozide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Pimozide's 24. In the major band specifically: Paroxetine has 3 (also Linezolid, Thioridazine); Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir).
What mechanism field is on file for Paroxetine and Pimozide?
Paroxetine slows down how your body processes pimozide, causing the drug to build up to unsafe levels. High levels of pimozide can cause the heart to beat in a dangerous and irregular way.
Pimozide carries more major-labeled pairs than Paroxetine
SPL source-record counts only. This page's band is major · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Pimozide (Typical Antipsychotic).
Pimozide has 12 major-labeled pairs vs Paroxetine's 3.
3 major · 4 moderate · 44 minor · 51 total
- Other major peers for Paroxetine
- Linezolid
- Thioridazine
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.