Paroxetine and Tranylcypromine Interaction
Drug interaction information between Paroxetine and Tranylcypromine.
Paroxetine and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Paroxetine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both affect the same brain chemicals, and using them together can cause your body to react poorly.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Pimozide and Thioridazine Clinical Impact Increased plasma concentrations of pimozide and thioridazine, drugs with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Selegiline moderate
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Tranylcypromine's 42. In the moderate band specifically: Paroxetine has 4 (also Phenelzine, Selegiline, Tamsulosin); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Paroxetine and Tranylcypromine?
These medications both affect the same brain chemicals, and using them together can cause your body to react poorly.
Tranylcypromine carries more major-labeled pairs than Paroxetine
SPL source-record counts only. This page's band is moderate · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Paroxetine's 3. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other moderate peers for Paroxetine
- Phenelzine
- Selegiline
- Tamsulosin
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.