Paroxetine and Buspirone Interaction
Drug interaction information between Paroxetine and Buspirone.
Paroxetine and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Paroxetine and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase a brain chemical called serotonin. Taking them together can cause these levels to get too high, which may be dangerous.
FDA Label Information
Examples other SSRIs, SNRIs, triptans, tricyclic antidepressants, opioids, lithium, tryptophan, buspirone, amphetamines and St.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Paroxetine has 44 (also Clopidogrel, Aspirin, Venlafaxine, Warfarin); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Paroxetine and Buspirone?
Both drugs increase a brain chemical called serotonin. Taking them together can cause these levels to get too high, which may be dangerous.
Paroxetine carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Buspirone (Azapirone Anxiolytic).
Paroxetine has 3 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Clopidogrel
- Aspirin
- Venlafaxine
- Warfarin
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.