Paroxetine and Venlafaxine Interaction
Drug interaction information between Paroxetine and Venlafaxine.
Paroxetine and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Paroxetine and Venlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine can interfere with how your body processes venlafaxine. This can cause the levels of venlafaxine in your blood to rise.
FDA Label Information
Examples propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Venlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Venlafaxine's 22. In the minor band specifically: Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Warfarin); Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Warfarin).
What mechanism field is on file for Paroxetine and Venlafaxine?
Paroxetine can interfere with how your body processes venlafaxine. This can cause the levels of venlafaxine in your blood to rise.
Paroxetine carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Paroxetine has 3 major-labeled pairs vs Venlafaxine's 0. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Warfarin
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.