What the FDA labels say about taking them together
Aspirin and paroxetine
Paroxetine's FDA label of February 12, 2026 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name paroxetine. The paroxetine label: “Examples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact PAXIL is highly bound to plasma protein. …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the aspirin label say about paroxetine?
Aspirin's label (effective September 9, 2025) does not name paroxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the paroxetine label say about aspirin?
Paroxetine label, drug interactionsExamples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact Paroxetine tablets are highly bound to plasma protein. The concomitant use of paroxetine tablets with another drug that is highly bound to plasma protein may increase free concentrations of paroxetine tablets or other tightly-bound drugs in plasma. Intervention Monitor for adverse reactions and reduce dosage of paroxetine tablets or other protein-bound drugs as warranted.
Paroxetine label, warnings and precautionsIncreased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.
Paroxetine Hydrochloride label (Apotex Corp, September 16, 2026), drug interactionsExamples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact Paroxetine HCL CR is highly bound to plasma protein. The concomitant use of Paroxetine HCL CR with another drug that is highly bound to plasma protein may increase free concentrations of Paroxetine HCL CR or other tightly-bound drugs in plasma. Intervention Monitor for adverse reactions and reduce dosage of Paroxetine HCL CR or other protein-bound drugs as warranted.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsDrugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, and Warfarin) Altered anticoagulant effects, including increased bleeding, have been reported when SSRIs are concomitantly administered with NSAIDs, aspirin, warfarin. or other drugs that affect coagulation.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), warnings and precautionsCaution patients about the risk of bleeding associated with the concomitant use of BRISDELLE and non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, or other drugs that affect coagulation ( 5.4 , 7.1 ) Angle-Closure Glaucoma:
Source: FDA drug label (Paroxetine Hydrochloride, NDA020936), Apotex Corp, effective September 16, 2026 (SPL set 087ff0d3-1761-47ea-a8c1-7c4cb679af97), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Paroxetine | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once