Paroxetine and Aspirin Interaction
Drug interaction information between Paroxetine and Aspirin.
Paroxetine and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Paroxetine and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications compete to bind with proteins in your bloodstream. This can lead to more of the drug being active in your system at once.
FDA Label Information
Examples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact Paroxetine is highly bound to plasma protein.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Aspirin's 47. In the minor band specifically: Paroxetine has 44 (also Buspirone, Clopidogrel, Venlafaxine, Warfarin); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Paroxetine and Aspirin?
Both medications compete to bind with proteins in your bloodstream. This can lead to more of the drug being active in your system at once.
Paroxetine's labeled portfolio outnumbers Aspirin
SPL source-record counts only. This page's band is minor · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Aspirin (Antiplatelet / NSAID).
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Venlafaxine
- Warfarin
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.