Paroxetine and Warfarin Interaction
Drug interaction information between Paroxetine and Warfarin.
Paroxetine and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Paroxetine and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine can interfere with how warfarin is processed and how it binds to blood proteins. This can increase the risk of bleeding.
FDA Label Information
For patients taking warfarin, carefully monitor the international normalized ratio [see Warnings and Precautions ( 5.5 )] . Examples aspirin, clopidogrel, heparin, warfarin Drugs Highly Bound to Plasma Protein Clinical Impact Paroxetine is highly bound to plasma protein. Examples warfarin Drugs Metabolized by CYP2D6 Clinical Impact Paroxetine is a CYP2D6 inhibitor [see Clinical Pharmacology ( 12.3 )] .
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Paroxetine's 51. In the minor band specifically: Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Paroxetine and Warfarin?
Paroxetine can interfere with how warfarin is processed and how it binds to blood proteins. This can increase the risk of bleeding.
Paroxetine carries more major-labeled pairs than Warfarin
SPL source-record counts only. This page's band is minor · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Paroxetine has 3 major-labeled pairs vs Warfarin's 2. This page itself is in the minor band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.