What the FDA labels say about taking them together
Paroxetine and warfarin
Paroxetine's FDA label of February 12, 2026 names warfarin in its drug interactions section, and warfarin's label names paroxetine too. The paroxetine label: “… of PAXIL and antiplatelet agents and anticoagulants. For patients taking warfarin, carefully monitor the international normalized ratio.”
Check it at the source: the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the paroxetine label say about warfarin?
Paroxetine label, drug interactionsIntervention; Inform patients of the increased risk of bleeding associated with the concomitant use of paroxetine tablets and antiplatelet agents and anticoagulants. For patients taking warfarin, carefully monitor the international normalized ratio [see ].
Paroxetine label, warnings and precautionsIncreased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs, other antiplatelet drugs, warfarin, and other anticoagulant drugs may increase risk.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), drug interactionsDrugs Highly Bound to Plasma Protein (e.g., Warfarin) Increased free plasma concentrations The warfarin dosage may need to be reduced. Monitor tolerability and the International Normalized Ratio.
Brisdelle label (Legacy Pharma USA, Inc., April 28, 2025), warnings and precautionsConcomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may add to this risk [see Drug Interactions ( 7.3 )].
Source: FDA drug label (Paroxetine Hydrochloride, NDA020936), Apotex Corp, effective September 16, 2026 (SPL set 087ff0d3-1761-47ea-a8c1-7c4cb679af97), via openFDA
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
What does the warfarin label say about paroxetine?
Warfarin label, drug interactionsDrug Class: Serotonin Reuptake Inhibitors; Specific Drugs: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, fluvoxamine, milnacipran, paroxetine, sertraline, venlafaxine, vilazodone
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Paroxetine | Warfarin | |
|---|---|---|
| Labeled for | Depression, Anxiety, Menopause symptoms | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0611 per tablet 20 mg tablet | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once