Paroxetine and Phenelzine Interaction
Drug interaction information between Paroxetine and Phenelzine.
Paroxetine and Phenelzine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Paroxetine and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can cause a dangerous buildup of brain chemicals that may lead to a severe reaction.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Pimozide and Thioridazine Clinical Impact Increased plasma concentrations of pimozide and thioridazine, drugs with a narrow therapeutic index, may increase the risk of QTc prolongation and ventricular arrhythmias.
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Tranylcypromine moderate
- Selegiline moderate
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Phenelzine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Phenelzine's 27. In the moderate band specifically: Paroxetine has 4 (also Tranylcypromine, Selegiline, Tamsulosin); Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine).
What mechanism field is on file for Paroxetine and Phenelzine?
Taking these two drugs together can cause a dangerous buildup of brain chemicals that may lead to a severe reaction.
Paroxetine carries more major-labeled pairs than Phenelzine
SPL source-record counts only. This page's band is moderate · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
Paroxetine has 3 major-labeled pairs vs Phenelzine's 0. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other moderate peers for Paroxetine
- Tranylcypromine
- Selegiline
- Tamsulosin
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.