Itraconazole and Oxycodone Interaction
Drug interaction information between Itraconazole and Oxycodone.
Itraconazole and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Itraconazole and Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops your body from processing the pain medicine oxycodone, which can lead to higher levels of the drug in your blood.
FDA Label Information
Alfentanil Buprenorphine (IV and sublingual) Oxycodone a Sufentanil Monitor for adverse reactions.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Oxycodone's 28. In the minor band specifically: Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Venlafaxine); Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin).
What mechanism field is on file for Itraconazole and Oxycodone?
Itraconazole stops your body from processing the pain medicine oxycodone, which can lead to higher levels of the drug in your blood.
Itraconazole carries more major-labeled pairs than Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Itraconazole (Azole Antifungal); Oxycodone (Opioid Analgesic).
Itraconazole has 19 major-labeled pairs vs Oxycodone's 0. This page itself is in the minor band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Venlafaxine
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.