Oxycodone and Pregabalin Interaction
Drug interaction information between Oxycodone and Pregabalin.
Oxycodone and Pregabalin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxycodone and Pregabalin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both medications slow down brain activity, which can cause dangerous levels of sleepiness and slow your breathing.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Pregabalin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine); Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Carbamazepine).
What mechanism field is on file for Oxycodone and Pregabalin?
Both medications slow down brain activity, which can cause dangerous levels of sleepiness and slow your breathing.
Oxycodone's labeled portfolio outnumbers Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Oxycodone (Opioid Analgesic); Pregabalin (Anticonvulsant / Nerve Pain Agent).
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.