Itraconazole and Pimozide Interaction
Drug interaction information between Itraconazole and Pimozide.
Itraconazole and Pimozide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Pimozide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows down the removal of pimozide from your body, which can increase the risk of serious heart side effects.
FDA Label Information
Apixaban Rivaroxaban Vorapaxar Not recommended during and 2 weeks after itraconazole treatment. Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Methadone major
- Midazolam major
- Felodipine major
Pimozide Also Interacts With
- Aprepitant major
- Citalopram major
- Clarithromycin major
- Darunavir major
- Escitalopram major
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Pimozide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Pimozide's 24. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Methadone, Midazolam); Pimozide has 12 (also Aprepitant, Citalopram, Clarithromycin, Darunavir).
What mechanism field is on file for Itraconazole and Pimozide?
Itraconazole slows down the removal of pimozide from your body, which can increase the risk of serious heart side effects.
Itraconazole carries more major-labeled pairs than Pimozide
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Pimozide (Typical Antipsychotic).
Itraconazole has 19 major-labeled pairs vs Pimozide's 12.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Methadone
- Midazolam
12 major · 0 moderate · 12 minor · 24 total
- Other major peers for Pimozide
- Aprepitant
- Citalopram
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.