Itraconazole and Fluticasone Interaction
Drug interaction information between Itraconazole and Fluticasone.
Itraconazole and Fluticasone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Itraconazole and Fluticasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole can prevent your body from clearing fluticasone, which may increase the risk of steroid-related side effects.
FDA Label Information
Budesonide (inhalation) a Budesonide (non-inhalation) Ciclesonide (inhalation) Cyclosporine (IV) a Cyclosporine (non-IV) Dexamethasone a Fluticasone (inhalation) a Fluticasone (nasal)Methylprednisolone a Tacrolimus (IV) a Tacrolimus (oral) Monitor for adverse reactions.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Fluticasone Also Interacts With
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Fluticasone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Fluticasone's 7. In the minor band specifically: Itraconazole has 77 (also Meloxicam, Buspirone, Oxycodone, Venlafaxine); Fluticasone has 5 (also Fluticasone/Salmeterol, Fluticasone, Fluticasone/Vilanterol, Salmeterol).
What mechanism field is on file for Itraconazole and Fluticasone?
Itraconazole can prevent your body from clearing fluticasone, which may increase the risk of steroid-related side effects.
Itraconazole carries more major-labeled pairs than Fluticasone
SPL source-record counts only. This page's band is minor · classes on file: Itraconazole (Azole Antifungal); Fluticasone (Corticosteroid).
Itraconazole has 19 major-labeled pairs vs Fluticasone's 0. This page itself is in the minor band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Meloxicam
- Buspirone
- Oxycodone
- Venlafaxine
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Fluticasone
- Fluticasone/Salmeterol
- Fluticasone
- Fluticasone/Vilanterol
- Salmeterol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.