Itraconazole and Lurasidone Interaction
Drug interaction information between Itraconazole and Lurasidone.
Itraconazole and Lurasidone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Lurasidone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood.
What To Do
Avoid taking these two drugs together and for at least two weeks after your itraconazole treatment ends.
FDA Label Information
Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Pimozide major
- Methadone major
- Midazolam major
- Felodipine major
Lurasidone Also Interacts With
- Clarithromycin major
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Voriconazole major
- Diltiazem minor
Frequently Asked Questions
Can I take Itraconazole and Lurasidone together?
This is a major interaction. Avoid taking these two drugs together and for at least two weeks after your itraconazole treatment ends.
How serious is the interaction between Itraconazole and Lurasidone?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Itraconazole and Lurasidone interact?
Itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood.
Understanding the Itraconazole and Lurasidone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Itraconazole belongs to the Azole Antifungal class and Lurasidone belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Itraconazole stops the enzymes that process lurasidone, leading to a buildup of the medication in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Itraconazole has 116 total documented interactions on file in this dataset, and Lurasidone has 15. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two drugs together and for at least two weeks after your itraconazole treatment ends. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Itraconazole or Lurasidone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.