Oxycodone and Nalbuphine Interaction
Drug interaction information between Oxycodone and Nalbuphine.
Oxycodone and Nalbuphine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Nalbuphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications can lead to a dangerous increase in breathing problems and muscle weakness.
FDA Label Information
Intervention: Avoid concomitant use Examples: Butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants Clinical Impact: Oxycodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Phenytoin moderate
Nalbuphine Also Interacts With
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Linezolid minor
- Phenelzine minor
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Nalbuphine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Nalbuphine's 19. In the moderate band specifically: Oxycodone has 6 (also Carbamazepine, Rifampin, Buprenorphine, Butorphanol); Nalbuphine has 1.
What mechanism field is on file for Oxycodone and Nalbuphine?
Combining these medications can lead to a dangerous increase in breathing problems and muscle weakness.
Oxycodone's labeled portfolio outnumbers Nalbuphine
SPL source-record counts only. This page's band is moderate · classes on file: Oxycodone (Opioid Analgesic); Nalbuphine (Opioid Agonist-Antagonist).
0 major · 6 moderate · 22 minor · 28 total
- Other moderate peers for Oxycodone
- Carbamazepine
- Rifampin
- Buprenorphine
- Butorphanol
0 major · 1 moderate · 18 minor · 19 total
Nalbuphine has no other moderate-band peer in this dataset besides Oxycodone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.