Oxycodone and Trazodone Interaction
Drug interaction information between Oxycodone and Trazodone.
Oxycodone and Trazodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Oxycodone and Trazodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can increase the levels of a brain chemical called serotonin. Taking them together may cause too much serotonin to build up in your body.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Trazodone Also Interacts With
- Linezolid major
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Trazodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trazodone has 40 labeled pairs on file vs Oxycodone's 28. In the minor band specifically: Oxycodone has 22 (also Tramadol, Cyclobenzaprine, Pregabalin, Mirtazapine); Trazodone has 35 (also Tramadol, Buspirone, Clopidogrel, Rivaroxaban).
What mechanism field is on file for Oxycodone and Trazodone?
Both of these medications can increase the levels of a brain chemical called serotonin. Taking them together may cause too much serotonin to build up in your body.
Trazodone carries more major-labeled pairs than Oxycodone
SPL source-record counts only. This page's band is minor · classes on file: Oxycodone (Opioid Analgesic); Trazodone (Serotonin Antagonist and Reuptake Inhibitor (SARI)).
Trazodone has 1 major-labeled pair vs Oxycodone's 0. This page itself is in the minor band, not the major band.
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
- Mirtazapine
1 major · 4 moderate · 35 minor · 40 total
- Other minor peers for Trazodone
- Tramadol
- Buspirone
- Clopidogrel
- Rivaroxaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.