Itraconazole and Buspirone Interaction
Drug interaction information between Itraconazole and Buspirone.
Itraconazole and Buspirone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Itraconazole and Buspirone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzyme that breaks down buspirone, which can cause the anxiety medicine to build up in your body.
FDA Label Information
Antipsychotics, Anxiolytics and Hypnotics Alprazolam a Midazolam (IV) a Aripiprazole a Quetiapine Buspirone a Cariprazine Ramelteon Diazepam a Risperidone a Haloperidol a Suvorexant Monitor for adverse reactions.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Buspirone Also Interacts With
- Tranylcypromine moderate
- Ziprasidone moderate
- Citalopram minor
- Darunavir minor
- Desvenlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Buspirone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Buspirone's 17. In the minor band specifically: Itraconazole has 77 (also Fluticasone, Meloxicam, Oxycodone, Venlafaxine); Buspirone has 15 (also Citalopram, Darunavir, Desvenlafaxine, Diltiazem).
What mechanism field is on file for Itraconazole and Buspirone?
Itraconazole blocks the enzyme that breaks down buspirone, which can cause the anxiety medicine to build up in your body.
Itraconazole carries more major-labeled pairs than Buspirone
SPL source-record counts only. This page's band is minor · classes on file: Itraconazole (Azole Antifungal); Buspirone (Azapirone Anxiolytic).
Itraconazole has 19 major-labeled pairs vs Buspirone's 0. This page itself is in the minor band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Oxycodone
- Venlafaxine
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Buspirone
- Citalopram
- Darunavir
- Desvenlafaxine
- Diltiazem
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.