What the FDA labels say about taking them together
Itraconazole and venlafaxine
Itraconazole's FDA label of July 13, 2026 names venlafaxine in its drug interactions section; the venlafaxine labels PlainMeds reads (3) do not name itraconazole. The itraconazole label: “SSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the itraconazole label say about venlafaxine?
Itraconazole label, drug interactionsSSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the venlafaxine label say about itraconazole?
Venlafaxine's label (effective August 15, 2023) and its 2 other brand-application labels do not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Venlafaxine | |
|---|---|---|
| Labeled for | Fungal infections | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.0799 per capsule 75 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once