Itraconazole and Venlafaxine Interaction
Drug interaction information between Itraconazole and Venlafaxine.
Itraconazole and Venlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Itraconazole and Venlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole slows down how your body gets rid of venlafaxine, which may increase the amount of antidepressant in your system.
FDA Label Information
SSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Venlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Metoprolol minor
- Fluoxetine minor
- Alprazolam minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Venlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Venlafaxine's 22. In the minor band specifically: Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone); Venlafaxine has 20 (also Metoprolol, Fluoxetine, Alprazolam, Warfarin).
What mechanism field is on file for Itraconazole and Venlafaxine?
Itraconazole slows down how your body gets rid of venlafaxine, which may increase the amount of antidepressant in your system.
Itraconazole carries more major-labeled pairs than Venlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Itraconazole (Azole Antifungal); Venlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Itraconazole has 19 major-labeled pairs vs Venlafaxine's 0. This page itself is in the minor band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
0 major · 2 moderate · 20 minor · 22 total
- Other minor peers for Venlafaxine
- Metoprolol
- Fluoxetine
- Alprazolam
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.