Oxycodone and Buprenorphine Interaction
Drug interaction information between Oxycodone and Buprenorphine.
Oxycodone and Buprenorphine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Buprenorphine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxycodone can make the muscle-weakening effects of other drugs stronger and can cause your breathing to slow down significantly. This combination can be very dangerous for your lungs and muscles.
FDA Label Information
Intervention: Avoid concomitant use Examples: Butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants Clinical Impact: Oxycodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Butorphanol moderate
- Nalbuphine moderate
- Phenytoin moderate
Buprenorphine Also Interacts With
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Ketoconazole minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Buprenorphine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Buprenorphine has 29 labeled pairs on file vs Oxycodone's 28. In the moderate band specifically: Oxycodone has 6 (also Carbamazepine, Rifampin, Butorphanol, Nalbuphine); Buprenorphine has 1.
What mechanism field is on file for Oxycodone and Buprenorphine?
Oxycodone can make the muscle-weakening effects of other drugs stronger and can cause your breathing to slow down significantly. This combination can be very dangerous for your lungs and muscles.
Buprenorphine's labeled portfolio outnumbers Oxycodone
SPL source-record counts only. This page's band is moderate · classes on file: Oxycodone (Opioid Analgesic); Buprenorphine (Partial Opioid Agonist).
0 major · 6 moderate · 22 minor · 28 total
- Other moderate peers for Oxycodone
- Carbamazepine
- Rifampin
- Butorphanol
- Nalbuphine
0 major · 1 moderate · 28 minor · 29 total
Buprenorphine has no other moderate-band peer in this dataset besides Oxycodone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.