Oxycodone and Butorphanol Interaction
Drug interaction information between Oxycodone and Butorphanol.
Oxycodone and Butorphanol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Oxycodone and Butorphanol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both slow down your breathing and can make your muscles very weak when taken together.
FDA Label Information
Intervention: Avoid concomitant use Examples: Butorphanol, nalbuphine, pentazocine, buprenorphine Muscle Relaxants Clinical Impact: Oxycodone may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression.
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Nalbuphine moderate
- Phenytoin moderate
Butorphanol Also Interacts With
- Acetaminophen/Oxycodone minor
- Buprenorphine (Pain) minor
- Codeine minor
- Fentanyl minor
- Hydromorphone minor
Frequently Asked Questions
What SPL severity band is on file for Oxycodone + Butorphanol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Butorphanol's 11. In the moderate band specifically: Oxycodone has 6 (also Carbamazepine, Rifampin, Buprenorphine, Nalbuphine); Butorphanol has 1.
What mechanism field is on file for Oxycodone and Butorphanol?
These drugs both slow down your breathing and can make your muscles very weak when taken together.
Oxycodone's labeled portfolio outnumbers Butorphanol
SPL source-record counts only. This page's band is moderate · classes on file: Oxycodone (Opioid Analgesic); Butorphanol (Opioid Agonist-Antagonist).
0 major · 6 moderate · 22 minor · 28 total
- Other moderate peers for Oxycodone
- Carbamazepine
- Rifampin
- Buprenorphine
- Nalbuphine
0 major · 1 moderate · 10 minor · 11 total
Butorphanol has no other moderate-band peer in this dataset besides Oxycodone.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.