Itraconazole and Midazolam Interaction
Drug interaction information between Itraconazole and Midazolam.
Itraconazole and Midazolam have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the breakdown of midazolam, making its calming effects much stronger and potentially dangerous.
FDA Label Information
Antipsychotics, Anxiolytics and Hypnotics Alprazolam a Midazolam (IV) a Aripiprazole a Quetiapine Buspirone a Cariprazine Ramelteon Diazepam a Risperidone a Haloperidol a Suvorexant Monitor for adverse reactions. Lurasidone Midazolam (oral) a Pimozide Triazolam a Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Felodipine major
Midazolam Also Interacts With
- Darunavir major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
- Erythromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Midazolam?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Midazolam's 39. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Midazolam has 3 (also Darunavir, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Itraconazole and Midazolam?
Itraconazole blocks the breakdown of midazolam, making its calming effects much stronger and potentially dangerous.
Itraconazole carries more major-labeled pairs than Midazolam
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Midazolam (Benzodiazepine).
Itraconazole has 19 major-labeled pairs vs Midazolam's 3.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
3 major · 9 moderate · 27 minor · 39 total
- Other major peers for Midazolam
- Darunavir
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.