Itraconazole and Isavuconazonium Interaction
Drug interaction information between Itraconazole and Isavuconazonium.
Itraconazole and Isavuconazonium have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Isavuconazonium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels.
FDA Label Information
Antihelminthics, Antifungals and Antiprotozoals Isavuconazonium Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
- Felodipine major
Isavuconazonium Also Interacts With
- Atorvastatin moderate
- Bupropion moderate
- Cyclosporine moderate
- Midazolam moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Isavuconazonium?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Isavuconazonium's 9. In the major band specifically: Itraconazole has 19 (also Lurasidone, Pimozide, Methadone, Midazolam); Isavuconazonium has 1.
What mechanism field is on file for Itraconazole and Isavuconazonium?
Itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels.
Itraconazole carries more major-labeled pairs than Isavuconazonium
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Isavuconazonium (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Isavuconazonium's 1.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Lurasidone
- Pimozide
- Methadone
- Midazolam
1 major · 5 moderate · 3 minor · 9 total
Isavuconazonium has no other major-band peer in this dataset besides Itraconazole.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.