What the FDA labels say about taking them together
Isavuconazonium and itraconazole
Itraconazole's FDA label of July 13, 2026 names isavuconazonium in its drug interactions section; isavuconazonium's label does not name itraconazole itself but warns about its class (Azole antifungals). The itraconazole label: “Antihelminthics, Antifungals and Antiprotozoals Isavuconazonium Contraindicated during and 2 weeks after TOLSURA treatment. Praziquantel Monitor for adverse reactions.”
Check it at the source: the isavuconazonium FDA label on DailyMed (effective April 25, 2025, Astellas Pharma US, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the isavuconazonium label say about itraconazole?
Isavuconazonium's label does not name itraconazole itself; it warns about its class (Azole antifungals):
Isavuconazonium label, warnings and precautionsAnaphylactic reactions, with fatal outcome, have been reported during treatment with CRESEMBA. Serious skin reactions, such as Stevens-Johnson syndrome, have been reported during treatment with other azole antifungal agents.
Isavuconazonium label, warnings and precautionsCases of more severe hepatic adverse drug reactions including hepatitis, cholestasis or hepatic failure including death have been reported in patients with serious underlying medical conditions (e.g., hematologic malignancy) during treatment with azole antifungal agents, including CRESEMBA.
Source: FDA drug label (CRESEMBA), Astellas Pharma US, Inc., effective April 25, 2025 (SPL set 8f7f73b8-586a-4df0-935f-fecd4696c16c), via openFDA; the full label on DailyMed
What does the itraconazole label say about isavuconazonium?
Itraconazole label, drug interactionsAntihelminthics, Antifungals and Antiprotozoals Isavuconazonium Contraindicated during and 2 weeks after SPORANOX ® treatment. Praziquantel Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isavuconazonium | Itraconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $114.00 per capsule 186 mg capsule | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once