Itraconazole and Meloxicam Interaction
Drug interaction information between Itraconazole and Meloxicam.
Itraconazole and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Itraconazole and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole may cause the level of meloxicam in your blood to decrease, which could make the pain reliever less effective.
FDA Label Information
Nonsteroidal Anti-Inflammatory Drugs Meloxicam a Concomitant drug dose increase may be necessary.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Meloxicam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Itraconazole has 77 (also Fluticasone, Buspirone, Oxycodone, Venlafaxine); Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Itraconazole and Meloxicam?
Itraconazole may cause the level of meloxicam in your blood to decrease, which could make the pain reliever less effective.
Itraconazole carries more major-labeled pairs than Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Itraconazole (Azole Antifungal); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
Itraconazole has 19 major-labeled pairs vs Meloxicam's 0. This page itself is in the minor band, not the major band.
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Buspirone
- Oxycodone
- Venlafaxine
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.